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CAS 23593-75-1 USP36 API And Intermediates White Crystal Powder Clotrimazole

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CAS 23593-75-1 USP36 API And Intermediates White Crystal Powder Clotrimazole

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Brand Name : AJA

Place of Origin : Anhui China

MOQ : 1KG

Price : USD10-20/kg

Packaging Details : 25KG/drum

CAS NO : 23593-75-1

EINEC NO : 245-764-8

MF : C22H17ClN2

MW : 344.84

Apperance : White Crystalline Powder

Usage : API

Package : 25kg/drum

Purity : 99%

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API Pharmaceutical Intermeidates White Crystal PowderClotrimazole

Product Name: Clotrimazole

Standard: USP31/BP2007/CP2005

CAS No:23593-75-1

Molecular Formula: C22H17ClN2

Molecular Weight: 344.84


Introduction:

Clotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.

Medical uses

It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops. Fungal infections can be slow to clear up, so the usual course for an anti-fungal agent is, in general, longer than the typical 3–7 days of an antibiotic. Clotrimazole is also commonly found in conjunction with Betamethasone, known as Lotriderm, to add steroid properties. Additionally, Clotrimazole is used to treat the sickling of cells (related to sickle cell anemia) by blocking ion channels in the RBC (red blood cell) membrane, keeping ions and water within the cell.


Main Function;

1. Clotrimazole is an anti-fungal medication commonly used in the treatment of fungal infections of both humans and

other animals suchas vaginal yeast infections. oral thrush, and ringworm.

2. It is also used to treat athlets's foot and jock itch.


Certificate of Analysis:


SpecificationStandardResult
CharactersWhite to pale yellow crystalline powderA white crystallin powder

Identification:

A. Infrared absoption


B. TLC Idetification TEST

The IRspectrum of sample, exhibits maxima only at the same wavelength as that a similar preparation of USPClotrimazole RS.


The RF value of the principal spot obtained from the test solution corresponds to that obtained from the Standar solution.

Complies.
Melting Point141 to 145°C142.5 to 143.5°C
Loss on dryingNot more than 0.5%0.2%
Residue on ignitionNot more than 0.1%0.05%
Heavy metalsNot more than 0.001%Complies.
Limit of imidazoleNot more than 0.5%0.21%
Limit of clotrimazole related compound ANot more than 0.5%0.1%
Assay(on the dried basis)Not less than 98% and not more than 102%99.8%
CONCLUSIONUP TO USP36 STANDARD



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USP36 API And Intermediates

      

clotrimazole antifungal powder

      
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