API Pharmaceutical Intermeidates White Crystal PowderClotrimazole
Product Name: Clotrimazole
Molecular Formula: C22H17ClN2
Molecular Weight: 344.84
Clotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of
fungal infections (of both humans and other animals) such as
vaginal yeast infections, oral thrush, and ringworm. It is also
used to treat athlete's foot and jock itch.
It is commonly available as an over-the-counter substance in
various dosage forms, such as a cream, and also (especially in the
case of ear infection) as a combination medicine. It is also
available as a troche or throat lozenge (prescription only). For
ear infection, it is often applied in liquid form, as ear drops.
Fungal infections can be slow to clear up, so the usual course for
an anti-fungal agent is, in general, longer than the typical 3–7
days of an antibiotic. Clotrimazole is also commonly found in
conjunction with Betamethasone, known as Lotriderm, to add steroid
properties. Additionally, Clotrimazole is used to treat the
sickling of cells (related to sickle cell anemia) by blocking ion
channels in the RBC (red blood cell) membrane, keeping ions and
water within the cell.
1. Clotrimazole is an anti-fungal medication commonly used in the
treatment of fungal infections of both humans and
other animals suchas vaginal yeast infections. oral thrush, and
2. It is also used to treat athlets's foot and jock itch.
Certificate of Analysis:
|Characters||White to pale yellow crystalline powder||A white crystallin powder|
A. Infrared absoption
B. TLC Idetification TEST
The IRspectrum of sample, exhibits maxima only at the same
wavelength as that a similar preparation of USPClotrimazole RS.
The RF value of the principal spot obtained from the test solution
corresponds to that obtained from the Standar solution.
|Melting Point||141 to 145°C||142.5 to 143.5°C|
|Loss on drying||Not more than 0.5%||0.2%|
|Residue on ignition||Not more than 0.1%||0.05%|
|Heavy metals||Not more than 0.001%||Complies.|
|Limit of imidazole||Not more than 0.5%||0.21%|
|Limit of clotrimazole related compound A||Not more than 0.5%||0.1%|
|Assay(on the dried basis)||Not less than 98% and not more than 102%||99.8%|
|CONCLUSION||UP TO USP36 STANDARD|